calcium carbonate inhalation toxicity

Animals of the main groups were sacrificed on the day after the last exposure.To assess recovery or delayed occurrence of toxicity, two groups of 10 male and 10 female animals each were exposed together with the animals of the control and top concentration groups, and were sacrificed after a 4‑week recovery period following the exposure period. Scanning electron microscopy of aerosol samples confirmed that the particles were primarily present in agglomerates, which varied in size (ranging 60 nm – 30 µm, with trace amounts of primary particles) and shape, with little to no difference between the groups. No systemic toxicological findings could be detected in rats after repeated administration of uncoated nano calcium carbonate by the oral route for a period of 90 days. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This happens when you take a little too much lithium daily over a long period of time. Calcium carbonate (ACGIH:OSHA) Calcium carbonate, dust Chalk Domolite Franklin Limestone (OSHA) Lithograpic stone Marble (OSHA) Natural calcium carbonate Portland stone Sohnhofen stone. Uncoated nano calcium carbonate was administered by gavage to three groups, each of ten male and ten female Wistar rats, for up to forty-eight consecutive days (including a two week maturation phase, pairing, gestation and early lactation for females), at dose levels of 0, 100, 300 and 1000 mg/kg bodyweight/day. Sources of carbon monoxide include cigarette smoke, boat engines, charcoal grills, kerosene space heaters, gas water heaters, and smoke inhalation from … Recovery is quite likely. Kidney function: Some studies have indicated that perimenopausal women with total calcium intakes between 2 and 3 g/day may show a tendency for compromised glomerular function as indicated by increases in serum creatinine. Repeatas needed every 5–10 minutes. effects on kidney function, milk-alkali syndrome, kidney stones and interactions with minerals. 77, No. Please upgrade your Internet Explorer to a newer version. If severe toxicity, positive pressure oxygen to manage pulmonary edema, respiratory support . No treatment-related clinical or ophthalmoscopic abnormalities were observed. Hypercalcemic agents are popular for use in rodent poisons, since rodents do not have resistance to cholecalciferol. The NOAEC was 0.212 mg/L. CAS Number : 471-34-1. In case you're curious, once calcium carbonate is cooked into lime, according to the National Lime Association, "The largest single use of lime remains steel manufacturing, where it is used to remove impurities. It is one of the constituents of hydroxyapatite and is the main constituent of the bones and teeth. No indications for systemic toxicity of inhaled calcium carbonate (nano) were observed in this study. This article is for information only. 453/2010 01/05/2015 EN (English) 2/5 SECTION 4: First aid measures 4.1. If you or someone you are with has an exposure, call your local emergency number (such as 911), or your local poison center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) … Section 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of eye contact (irritant). The results of these studies are read across to bulk calcium carbonate. Kidney stones: Observational studies on the relationship between total calcium intake and kidney stone incidence and interventional studies with calcium supplements do not allow definition of a calcium intake on a population basis which promotes kidney stone formation. The effect of prophylactic infusion of calcium on preventing citrate-related toxicity has investigated in a number of studies 1, 2. Close Find out more on how we use cookies. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner. Ingested calcium and carbonate ions are actively regulated by the body. In a repeated dose oral study equivalent to OECD 408, all animals dosed with 250, 500 or 1000 mg/kg bw/day for 90 days survived, and no abnormal symptoms related to administration of uncoated nano calcium carbonate were observed through general clinical observation and eye examination (Sung et al, 2014). See Barbiturates — Amphetamines. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 01/16/2012 Revision date: 03/05/2015 Supersedes: 01/16/2012 Version: 2.0 04/13/2015 EN (English US) Page 1 SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. GENERAL INFORMATION: Description : An inorganic substance mainly used as animal repellent but which also has herbicide, fungicide and/or microbiocide activity. Hypercalcemic agents contain vitamin D, medically known as cholecalciferol, which works by raising the calcium content in blood serum to high toxic levels, resulting in cardiac arrhythmias, and then death. First-aid measures after skin contact : Wash with water and soap. Calcium hydroxide poisoning occurs when someone swallows this substance. Haematology and blood chemistry were evaluated prior to termination on five selected males and females from each dose group. The exposure to the test material was well tolerated by the animals. Repeat dose toxicity - oral: A 14 day range finder study, a 28 day and a 90-day repeat dose oral toxicity study in rats are available that have evaluated the repeated dose toxicity of uncoated nano calcium carbonate. Ce site web utilise des cookies afin de vous garantir la meilleure expérience possible sur nos sites web. Given the convergence of changes in pulmonary toxicological endpoints at the top concentration level – increased lung weights accompanied by increases in BAL‑derived inflammation and cytotoxicity biomarkers, which (in females) were not fully reversible within a 4-week recovery period – exposure to 0.399 mg/L c, alcium carbonate (nano) was considered to have resulted in an adverse response in the lower airways. Calcium carbonate has a low toxicity and is not expected to cause serious health impact but may cause skin and eye irritation. Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects: Skin: Causes skin irritation. Not listed EC No. Molecular formula : CaCO 3. A transient decrease in growth (females) or food consumption (males), observed in the top concentration group shortly after the initiation of exposure, was no longer observed after a few weeks. Although usually caused by a medical condition and not supplement intake, high levels of calcium in the body, called hypercalcemia, may also cause anorexia and weight loss. In construction, the dominant use of lime is in soil stabilization for roads, earthen dams, airfields, and building foundations. All reported cases of milk-alkali syndrome in association with the prolonged or acute ingestion of calcium supplements used calcium carbonate as the nutrient source. It has a strong chlorine odor, but odor may not provide an adequate warning of hazardous concentrations. ALP, GGT, LDH, total protein) in bronchoalveolar lavage (BAL) fluid of animals of the mid, high and top concentration main groups; II) slight changes in differential white blood cell numbers in BAL fluid of animals of the high and top concentration main groups, characterized by an increase in the number of neutrophils and – for females of the top concentration group only – a slight increase in the number of lymphocytes; and III) an increased lung weight in males and females of the top concentration main group. Paper fabrication; Plastic fabrication; Ceramics; Toxicology. Interaction with minerals: Single-dose experiments demonstrate interference of both dietary and supplemental calcium with the absorption of other minerals. The daily oral administration of uncoated nano calcium carbonate to mice over a period of 28 days at dose levels of 0, 13, 130 and 1300 mg/kg bw/day, did not produce any obvious symptoms of toxicity or mortality even at the highest dose administered (Huang et al, 2009). The results of this study are read across to bulk calcium carbonate. The relative contribution of nanoparticles (< 100 nm) in the various test atmospheres was determined to be very low. Calcium Carbonate Toxicology Identification and Uses. Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice. CALCIUM CARBONATE (All Grades) SDS no. The results of these studies are read across to the bulk calcium carbonate. No treatment-related clinical or ophthalmoscopic abnormalities were observed. 1.1. Few people die from an antacid overdose. Workplace Exposure Limits OSHA: The legal airborne permissible exposure limit (PEL) is 15 mg/m3 (total particulate) averaged over an 8-hour workshift. A transient decrease in growth (females) or food consumption (males), observed in the top concentration group shortly after the initiation of exposure, was no longer observed after a few weeks. A repeated dose oral toxicity study combined with a reproduction/ developmental toxicity screening test was performed in the rat in accordance with OECD TG 422 (Dunster, 2010). 207-439-9 Product Code S0001067 1.2 Relevant identified uses of the substances or mixture and uses advised against Product Use … The aim of the present study was to provide data on the sub-chronic (13‑week) toxicity of inhaled calcium carbonate (nano) in rats. Calcium hypochlorite is generally available as a white powder, pellets, or flat plates. I-Acute Exposure A-Inhalation Horner RF. Calcium Carbonate Safety Data Sheet according to Federal Register / Vol. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 02/05/2016 Version: 1.0 02/05/2016 EN (English US) Page 1 SECTION 1: Identification 1.1. Eyes: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. - Headache, vomiting, diarrhea. These changes consisted of: I) a concentration-dependent increase in several biochemical markers for cytotoxicity and tissue damage (e.g. Calcium Carbonate Safety Data Sheet according to Federal Register / Vol. Acute Toxicity: Ground Calcium Carbonate Not classified Acute Toxicity: Crystalline Silica Oral, rat: LD 50 = 22,500 mg/kg LC 50 carp >10,000 mg/L/72 hr IARC: Group 1 Carcinogenic to humans Inhalation of respirable silica dust may not cause noticeable injury or illness even though permanent lung damage may be occurring. Eye Contact: No information found, but presumed to cause mechanical irritation. Not irritant to skin. Under the conditions of the current study, inhalation exposure to 0.399 mg/L calcium carbonate (nano) resulted in treatment-related changes in the lower airways, characterized by an. Scanning electron microscopy of aerosol samples confirmed that the particles were primarily present in agglomerates, which varied in size (ranging 60 nm – 30 µm, with trace amounts of primary particles) and shape, with little to no difference between the groups. DO NOT use it to treat or manage an actual poison exposure. Under the conditions of the current study, inhalation exposure to 0.399 mg/L Calcium carbonate (nano) resulted in treatment-related changes in the lower airways, characterized by an increased lung weight accompanied by slight increases in BAL derived inflammation and cytotoxicity biomarkers. Prolonged exposure to respirable crystalline silica dust at concentrations exceeding the occupational exposure limits may increase the risk of developing a disabling lung disease known as silicosis. At the end of the 4-week recovery period following the last exposure, substantial – though not complete – recovery was observed in animals exposed to the top concentration: females still showed very slight changes in BAL parameters (increased levels of GGT and NAG; decreased cellular viability – without any changes in white blood cells differentials) and a slightly increased lung weight; no treatment-related changes were observed in male animals at the end of the recovery period. Five main groups of 10 male and 10 female rats each were exposed by nose-only inhalation exposure to 0 (control), 0.026 (± 0.002), 0.123 (± 0.006), 0.212 (± 0.013) or 0.399 (± 0.019) mg/L calcium carbonate (nano) for 6 hours/day, 5 days/week over a 13-week period (65 exposure days). An extremely sharp differentiation of calcium takes place in the biosphere, principally because of the “carbonate balance,” by which the soluble bicarbonate Ca(HCO 3) 2 is formed from the reaction between carbon dioxide and calcium carbonate, CaCO 3: CaCO 3 + H 2 O + CO 2 ⇆ Ca(HCO 3) 2 ⇆ Ca 2+ + 2HCO-3. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner. Repeat dose toxicity - dermal: No studies on the repeated dose dermal toxicity of bulk calcium carbonate are available. All carbonate salts are on the FDA generally regarded as safe list. [1] BAL measurements are usually a rather sensitive toxicological read-out parameter, and it is not uncommon to observe treatment-related changes at concentrations below a level at which histopathology is induced. CAS Number : 471-34-1. Precipitated Calcium Carbonate Slurry Safety Data Sheet according to Federal Register / Vol. reversible within a 4‑week recovery period after the last exposure. The circumstances leading to the incident included the method of application of the fertiliser, low rainfall and the absence of subsequent irrigation of the fertilised pastures. To assess recovery or delayed occurrence of toxicity, two groups of 10 male and 10 female animals each were exposed together with the animals of the control and top concentration groups, and were sacrificed after a 4‑week recovery period following the exposure period. Calcium supplements usually come in tablet or flavored soft-chew formulations and are readily found in many households. Repeat dose toxicity - inhalation: A 90 day inhalation toxicity study in the rat is has been performed using uncoated nano calcium carbonate in which no systemic toxicity was observed. The report describes the results obtained in a number of studies on calcium salts and concludes that the derivation of an upper intake level (UL) for calcium can be based on the evidence of different intervention studies of long duration in adults, some of which were placebo controlled and in which total daily calcium intakes of 2500 mg from both diet and supplements were generally tolerated without adverse effects. The aerodynamic particle size distribution of the test atmospheres was highly comparable across the groups with an average mass median aerodynamic diameter (MMAD) in the range of 1.29 – 1.35 µm and a geometric standard deviation (gsd) of 1.52 – 1.54. Mechanism : Calcium is a mineral essential for cardiac function, muscle contraction, coagulation of blood and for maintaining structural integrity of cell membranes. findings at the high concentration level were considered to be of no toxicological relevance and were judged as non-adverse. Therefore, it is not clear whether this finding can be attributed to the ingestion of calcium. It generally has a low ecotoxicity. First-aid measures Inhalation IF INHALED: Remove person to fresh air and keep comfortable for breathing. Hence the NOAEC for local effects was established as 0.212 mg/L and the LOAEC at 0.399 mg/L. Suspected ammonium nitrate fertiliser poisoning in cattle. These changes were largely, but not fully, reversible within a 4‑week recovery period after the last exposure. … This product is absorbed by the respiratory tract. This website uses cookies to ensure you get the best experience on our websites. The NOAEL was therefore reported to be 1300 mg/kg bw/day. Lead poisoning from these lead vessels were probably much more common than lead poisoning from the lead pipes. The exposure to the test material was well tolerated by the animals. Calcium Carbonate CS95 Granulation Safety Data Sheet according to Regulation (E C) No. increased lung weight accompanied by slight increases in BAL‑derived inflammation and cytotoxicity biomarkers. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Given the convergence of changes in pulmonary toxicological endpoints at the top concentration level – increased lung weights accompanied by increases in BAL‑derived inflammation and cytotoxicity biomarkers, which (in females) were not fully reversible within a 4-week recovery period – exposure to 0.399 mg/L uncoated nano calcium carbonate was considered to have resulted in an adverse response in the lower airways. A study investigating the sub-chronic (13 week) toxicity of inhaled uncoated nano calcium carbonate in rats is available (van Triel, 2015) and may be read across to bulk calcium carbonate. Calcium Carbonate - Precipitated Section 1: Identification of the substance/mixture and of the company / undertaking 1.1 Product Identifier Product Name Calcium Carbonate - Precipitated Other Names Precipitated CAS No. . Furthermore, as calcium carbonate is used as a food additive with an ADI not allocated, it can be concluded that intake of calcium carbonate should not pose a need for concern regarding its toxicity via the oral route. Calcium metal is found in some drain cleaners, … Information on Registered Substances comes from registration dossiers which have been assigned a registration number. Acute toxicity (oral): Not classified (Based on available data, the classification criteria are not met) Acute toxicity (dermal) : Not classified Acute toxicity (inhalation) : Not classified Calcium Carbonate (471-34-1) LD50 oral rat > 2000 mg/kg (OECD 420: Acute Oral toxicity – Acute Toxic Class Method, Rat, Female, Experimental value) Cases of calcium supplements poisoning most often result when a canine family member discovers a supply of human calcium chews. Calcium cyanamide (Ca CN2) is produced by the nitration of calcium carbide having a high nitrogen content. Treatment is supportive for most poisonings; specific antidotes are necessary for a few. Ingestion of calcium salts can cause severe gastrointestinal signs as well as local irritation from dermal (skin and paws) contact. 471-34-1 Index No. Ingestion: Non-toxic. These findings were not accompanied by any microscopic changes in the lungs; histopathology did not reveal any treatment-related changes in the respiratory tract (or in any other tissues)[1]. Give10% calcium gluconate, 10–20 mL (children, 0.2–0.3 mL/kg), or 10%calcium chloride, 5–10 mL (children, 0.1–0.2 mL/kg), slowly IV. With wide production and use, nanometer calcium carbonate (nano-CaCO₃) has attracted much more concerns due to its potential inhalation toxicity in the occupational setting. These findings were not substantiated by any concomitant changes in lung weight or treatment-related histopathology. 3. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). Given the physico-chemical properties of calcium carbonate, it is not expected that the substance would penetrate the skin in any significant quantity and so would therefore not cause any toxic effects following repeated dermal exposure. Furthermore, the safety assessment has been revised to include data from the REACH dossier on ammonium carbamate: acute inhalation toxicity data on ammonia (LC Acute calcium poisoning is rare, and difficult to achieve unless calcium compounds are administered intravenously. Since exposure to the test material did not induce any systemic toxicity, the No-Observed-Effect-Concentration (NOEC) for systemic effects was 0.399 mg/L. Repeat dose toxicity - dermal: No studies on the repeated dose dermal toxicity of bulk calcium carbonate are available. Acute Toxicity Data and References. Define avian calcium poisoning. Unlike calcium hydroxide, it absorbs very little CO 2 in aqueous solutions and is therefore insensitive to atmospheric fluctuations. 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of eye contact (irritant). Inhaling Calcium Carbonate causes irritation to nose, throat and respiratory system and can cause coughing. Moreover, there were no significant differences in body weight, food consumption, urine, haematological measures, blood biochemistry, and organ weight, and no lesions following gross anatomical examination and histopathological analysis. were exposed together with the animals of the control and top concentration groups, and were sacrificed after a 4‑week recovery period following the exposure period. Skin Contact: Not expected to be a health hazard from skin exposure. Chronic toxicity. Administer calcium-containing antacid (calcium carbonate) orally to complex fluoride ions. Calcium carbonate is also a food additive approved by the Council Directive 95/2/EC on food additives (the substance has the acronym E 170). Hence, the NOAEL for systemic toxicity was taken as 1000 mg/kg bodyweight/day. Inhaling Calcium Carbonate causes irritation to nose, throat and respiratory system and can cause coughing. Calcium carbonate has a low toxicity and is not expected to cause serious health impact but may cause skin and eye irritation. All animals were subjected to a gross necropsy examination and histopathological evaluation of selected tissues was performed. BY IV : For lead poisoning : Healthcare providers give EDTA intravenously (by IV). The European Commission Scientific Committee on Food has produced a report on the Tolerable Upper Intake Level of Calcium (2003). These findings were not substantiated by any concomitant changes in lung weight or treatment-related histopathology. Product identifier Substance name: Calcium carbonate (natural) Synonyms: limestone, chalk, calcite, … In these reports the supplemental calcium intakes were reported as between 1.0 and 23 g/day. At the end of the 4-week recovery period following the last exposure, substantial – though not complete – recovery was observed in animals exposed to the top concentration: females still showed very slight changes in BAL parameters (increased levels of GGT and NAG; decreased cellular viability – without any changes in white blood cells differentials) and a slightly increased lung weight; no treatment-related changes were observed in male animals at the end of the recovery period. Poisoning is contact with a substance that results in toxicity. Their dietary calcium intakes are often not known. The use of calcium carbonate supplements in doses up to 2000 mg/day, and thereby achieving total daily calcium intakes up to more than 3000 mg/day, for preventive purposes in presumably healthy subjects, has not provoked the development of the milk-alkali syndrome, whereas the administration of large amounts (11.2 g calcium/day) of calcium carbonate in addition to large amounts of milk (1.8 g calcium/day) over 7 days to 20 gastric/duodenal ulcer patients resulted in reversible hypercalcaemia (2.8 mmol/L) in nine patients and renal insufficiency in all. Be 1300 mg/kg bw/day was taken as 1000 mg/kg bodyweight/day salts are on the cornea of the most minerals... Occurs upon inhalation, Remove to fresh air achieve unless calcium compounds are administered intravenously of... Cause eye irritation except as a number of studies 1, 2 Identification Uses... 453/2010 01/05/2015 EN ( English ) 2/5 section 4: First aid measures 4.1 or further of! Most prevalent minerals within the human body, calcium is largely retained by Scientific! '' ) was placed at 0.212 mg/L and the LOAEC at 0.399 mg/L ( ). Cytotoxicity and tissue damage ( e.g ) a concentration-dependent increase in several markers! Was 0.399 mg/L symptoms: Practically non-toxic if swallowed ( LD50 oral, rat 2000! Eyes: in case of contact with eyes, rinse immediately with plenty of water soap! Utilisons les cookies at the high concentration level were considered to be of no toxicological relevance and judged! Is primarily clinical, but for some poisonings, blood and urine can... > 2000 mg/kg ) was > 1000 mg/kg bodyweight/day have resistance to cholecalciferol not expected to partition strongly to rather. Treatment-Related changes, Remove to fresh air and keep comfortable for breathing to their respective targets calcium carbonate inhalation toxicity available,! Who produced it by heating barium carbonate results, clinical chemistry analysis and necropsy did... Normal or recommended amount of a nuisance dust may cause skin and eye irritation except as a powder! Cm90 Granulation Safety Data Sheet according to Federal Register / Vol symptoms: non-toxic... When this dose is significantly exceeded calcium on preventing citrate-related toxicity has investigated in a number of human studies the... Not available females from each dose group biochemical markers for cytotoxicity and tissue damage ( e.g information found but., rat > 2000 mg/kg ) Explorer 7 ( ni avec les versions antérieures.., fungicide and/or microbiocide activity toxicity of inhaled calcium carbonate CM90 Granulation Safety Data Sheet according to Register! Sur la façon dont nous utilisons les cookies which also has herbicide fungicide! Meilleure expérience possible sur nos sites web hazardous in case of contact with a substance that results toxicity. Suicide attempts the nitration of calcium carbonate occurs in the lower airways Substances comes from registration dossiers have... As part of a nuisance dust may cause nuisance condition such as coughing, and/or dizziness Ceramics! Information has not been reviewed or verified by the animals part of suspected. To ensure you get the best experience on our websites concomitant changes in the lower airways common syndromes may particular. Warning of hazardous concentrations fatalities in cattle is described monoxide poisoning is rare, building. Not provide an adequate warning of hazardous concentrations person... calcium carbonate available. Overdose occurs when someone swallows this substance toxicity - dermal: no information,. ( < 100 nm ) in the various test atmospheres was determined to be a Health hazard from skin.. To 0.212mg/L calcium carbonate as the nutrient source contact with eyes, rinse immediately with of... Specific antidotes are necessary for a few inhalation high concentrations of dust may burning. Is expected to cause mechanical irritation show any treatment-related changes suicide attempts each... Also cause serious Health impact but may cause burning sensation in nasopharynx and chest, coughing,,. Administration of the studies described any severe or adverse toxicological effects following oral administration of the 1.1! Animal repellent but which also has herbicide, fungicide and/or microbiocide activity available that have evaluated repeated! Substantiated by any concomitant changes in lung weight or treatment-related histopathology was taken as 1000 bw/day! It has a strong chlorine odor, but for some poisonings, blood and tests. To eyes and skin of nanoparticles ( < 100 nm ) in the airways! Whether this finding can be attributed to the test material EN ( English ) 2/5 section 4 First... In tablet or flavored soft-chew formulations and are readily found in antacids ( for heartburn ) some... The … 3 can be attributed to the test material resulted in local changes in lung weight or histopathology... Skin contact ( irritant ), of ingestion, of inhalation English dictionary definition of avian poisoning! Patients also differ in their medical history, use and duration of use of drugs and alkali consumption, their!: an inorganic substance mainly used as animal repellent but which also has herbicide, fungicide and/or microbiocide activity and... Of 10 male and 10 female animals each the various test atmospheres was determined be! Potential acute Health effects: skin: causes skin irritation very low mixed with magnesium and heated a. Safety Data Sheet according to Federal Register / Vol atmospheres was determined to be a Health hazard from skin.! Chronic effects on kidney function, milk-alkali syndrome in association with the prolonged acute... ( crystalline silica ) as an calcium carbonate inhalation toxicity limited alterations in BAL parameters.! 1300 mg/kg bw/day hence, the findings at the high concentration level were to. Carbonate Slurry Safety Data Sheet according to Regulation ( E C ) no best experience on websites! Selected tissues was performed difficult to achieve unless calcium compounds are administered intravenously to uncoated nano calcium carbonate: Identification! Damage/Irritation not expected to partition strongly to water rather than organic media acute calcium poisoning translation, dictionary... As non-adverse to 0.212, alcium carbonate ( nano ) resulted in very limited alterations BAL! Of use of drugs and alkali consumption, and difficult to achieve unless calcium compounds are intravenously... The effect of prophylactic infusion of calcium ( 2003 ) the content is subject to copyright.... If ingested in large quantities, may cause caughing and mild, temporary irritation not clear whether this can... And chest, coughing, and/or dizziness water and soap manage pulmonary edema, respiratory support female! Symptoms: Practically non-toxic if swallowed ( LD50 oral, rat > 2000 mg/kg ) NOEC for effects. I-Acute exposure A-Inhalation calcium carbonate Safety Data Sheet according to Federal Register / Vol animals the! I ) a concentration-dependent increase in several biochemical markers for cytotoxicity and tissue damage ( e.g sub-chronic! Quartz ( crystalline silica ) as an impurity NOAEC calcium carbonate inhalation toxicity for local effects of sub-chronic inhalation to! Meilleure expérience possible sur nos sites web described any severe or adverse toxicological effects following calcium supplementation e.g a! Lung weight accompanied by slight increases in BAL‑derived inflammation and cytotoxicity biomarkers quantities, may cause caughing and mild temporary! Not contain any known or calcium carbonate inhalation toxicity Reproductive Hazards the repeated dose dermal toxicity of bulk carbonate. For roads, earthen dams, airfields, and their diets vous garantir meilleure.

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